GENOME-WIDE SCAN FOR RUNS OF HOMOZYGOSITY IDENTIFIES CANDIDATE GENES RELATED TO ECONOMICALLY IMPORTANT TRAITS IN CHINESE MERINO

Genome-Wide Scan for Runs of Homozygosity Identifies Candidate Genes Related to Economically Important Traits in Chinese Merino

In this study, we estimated the number, length, and frequency of runs of homozygosity (ROH) in 635 Chinese Merino and identified genomic regions with high ROH frequency using the OvineSNP50 whole-genome genotyping array.A total of 6039 ROH exceeding 1 Mb were wac 4011 detected in 634 animals.The average number of ROH in each animal was 9.23 and the

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Chronic Pruritus in Atopic Patients Treated with Dupilumab: Real Life Response and Related Parameters in 354 Patients

Chronic pruritus is a major symptom of atopic dermatitis (AD).Its etiopathogenesis is complex, and an understanding of the driving factors of its pathogenesis allows for the development of new molecule-targeted therapies.Dupilumab, targeting and blocking interleukin-4 (IL-4) and interleukin-13 (IL-13) molecules, has shown great efficacy in treating

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